کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5674879 | 1594206 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production](/preview/png/5674879.png)
چکیده انگلیسی
The iridovirus RNase III gene is one of 26 conserved core genes among the family Iridoviridae. Initial studies suggest this viral protein functions to suppress RNA interference pathways that may attack viral RNA during infection. Therefore, to determine if the Ambystoma tigrinum virus (ATV) RNase III-like gene (ORF 25R) can modulate the host innate immune response fish and human cells ectopically expressing 25R were treated with polyI:C and monitored for interferon synthesis and phosphorylation of eIF2α and PKR. We found a decrease in cellular IFN production and modulation of the PKR pathway. In addition, ATV deleted of the RNase III gene (ATVÎ25R) shows reduced pathogenicity in tiger salamanders. Collectively our data suggest that the ATV 25R protein is a pathogenesis factor that may function to help evade the host's immune response by masking activators of the IFN pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 511, November 2017, Pages 300-308
Journal: Virology - Volume 511, November 2017, Pages 300-308
نویسندگان
Alexander G. Allen, Scott Morgans, Eric Smith, Mariah M. Aron, James K. Jancovich,