کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5674942 | 1594208 | 2017 | 4 صفحه PDF | دانلود رایگان |
- Hepatitis B viral particles (VP) and subviral particles (SVP) were fractionated.
- SVP were efficient in protecting VP by adsorbing neutralizing anti-HBs antibodies.
- SVP were less efficient in blocking viral entry by binding to target cells.
- Thus, SVP may facilitate cell-to-cell spread in presence of neutralizing antibodies.
During hepatitis B virus (HBV) infections subviral particles (SVP) consisting mainly of hepatitis B surface antigen are present at much higher concentration than viral particles (VP) in serum. To investigate reasons for this excess of SVP production, SVP and VP were fractionated on a Nycodenz gradient and analyzed for HBV infection of HepG2-NTCP cells with and without anti-HBs antibodies. Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SVP had little effect on viral entry, supporting the assumption that SVP serve as decoy facilitating cell-to-cell spread of HBV in the presence of neutralizing antibodies.
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Journal: Virology - Volume 509, September 2017, Pages 67-70