کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5675043 | 1594209 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Enterovirus71 (EV71) is the major causative agent of hand, foot and mouth disease, which threatens the health of infants and young children. The expression of inflammatory cytokines induced by this viral infection aggravate the illness. Here, we describe the anti-EV71 activity of a specific p38 inhibitor that regulates the p38-MAPK signaling pathway. PD169316 was specifically selected from a MAPK compound library due to its significant inhibitory effect on EV71 replication. PD169316 also reduced EV71-induced apoptosis. Animal experiments showed that PD169316 can dampen the replication of EV71, reduce tissue damage and inhibit the release of inflammatory cytokines, thereby alleviating the severe diseases caused by EV71 in suckling mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 508, August 2017, Pages 150-158
Journal: Virology - Volume 508, August 2017, Pages 150-158
نویسندگان
Zhe Zhang, Busen Wang, Shipo Wu, Yanbo Wen, Xinyi Wang, Xiaohong Song, Jinlong Zhang, Lihua Hou, Wei Chen,