کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5675112 1594211 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Partial dysfunction of STAT1 profoundly reduces host resistance to flaviviral infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Partial dysfunction of STAT1 profoundly reduces host resistance to flaviviral infection
چکیده انگلیسی


- Routinely maintained inbred MHC-II knockout mice spontaneously acquired a mutation.
- Spontaneous mutation resulted in increased susceptibility to flaviviral infection.
- Sequence capture and sequencing identified the mutation as Y37L substitution in STAT1 gene.
- The mutation in STAT1 gene gave a partial inactivation of the type I interferon antiviral pathway.

The genetic basis for a dramatically increased virus susceptibility phenotype of MHC-II knockout mice acquired during routine maintenance of the mouse strain was determined. Segregation of the susceptibility allele from the defective MHC-II locus combined with sequence capture and sequencing showed that a Y37L substitution in STAT1 accounted for high flavivirus susceptibility of a newly derived mouse strain, designated Tuara. Interestingly, the mutation in STAT1 gene gave only partial inactivation of the type I interferon antiviral pathway. Accordingly, merely a relatively small impairment of interferon α/β signalling is sufficient to overcome the ability of the host to control the infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 506, June 2017, Pages 1-6
نویسندگان
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