کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5678596 | 1596417 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of the use of a TNF-alpha inhibitor in hypothermic machine perfusion on kidney function after transplantation
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کلمات کلیدی
HMPPRADGFPRUCITECDSCDTNFTITRheumatoid arthritis - آرتریتروماتوئیدIschemia-reperfusion injury - آسیب ایسکمی ـ باز خون رسانی یا آسیب ناشی از ایسکمی و برقراری مجدد جریان خونPanel reactive antibody - آنتی بادی واکنش پانلexpanded criteria donors - اهدا کنندگان معیار گسترش یافتهdelayed graft function - تاخیر در عملکرد گاو نرUniversity of Wisconsin - دانشگاه ویسکانسینTreatment - درمانPeritoneal dialysis - دیالیز صفاقیCold storage - ذخیرهسازی سردAcute rejection - رد حادcold ischemia time - زمان سرد ایسکمیprimary non-function - غیرفعال اولیهconfidence interval - فاصله اطمینانtumor necrosis factor - فاکتور نکروز تومورBrain death - مرگ مغزیhazard ratio - نسبت خطرHemodialysis - همودیالیزPNF - پاپHypothermic machine perfusion - پرفیوژن دستگاه هیپوترمیRegenerative medicine - پزشکی ترمیمیKidney transplantation - پیوند کلیه
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
One of the most important problems in transplantation medicine is the ischemia/reperfusion injury of the organs to be transplanted. The aim of the present study was to assess the effect of tumor necrosis factor-alpha (TNF-alpha) inhibitor etanercept on the machine perfusion hypothermia of renal allograft kidney function and organ perfusion. No statistically significant differences were found in the impact of the applied intervention on kidney machine perfusion during which the average flow and vascular resistance were evaluated. There were no statistically significant differences in the occurrence of delayed graft function (DGF). Fewer events in patients who received a kidney from the etanercept treated Group A compared to the patients who received a kidney from the control Group B were observed when comparing the functional DGF and occurrence of acute rejection episodes, however, there was no statistically significant difference. In summary, no effect of treatment with etanercept an inhibitor of TNF-alpha in a hypothermic machine perfusion on renal allograft renal survival and its perfusion were detected in this study. However, treatment of the isolated organ may be important for the future of transplantation medicine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 59, August 2017, Pages 44-50
Journal: Contemporary Clinical Trials - Volume 59, August 2017, Pages 44-50
نویسندگان
Piotr Diuwe, Piotr Domagala, Magdalena Durlik, Janusz Trzebicki, Andrzej Chmura, Artur Kwiatkowski,