کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5682411 1597723 2017 43 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Photodynamic therapy in dermatology beyond non-melanoma cancer: An update
ترجمه فارسی عنوان
درمان فوتودینامیک در پوست در برابر سرطان غیر ملانوم: به روز رسانی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology, PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 19, September 2017, Pages 140-152
نویسندگان
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