کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5685112 | 1597932 | 2016 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth
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کلمات کلیدی
LGAHWAANGPTL8adequate for gestational ageHOMA-BMBAGDMOGTTAGASGASSFBATHOMA-IRHBAhASCs - HASCsUcp1 - UCP1Oral glucose tolerance test - آزمون تحمل گلوکز خوراکیWAT, White adipose tissue - بافت چربی سفید، بافت ادیپوز سفیدbrown adipose tissue - بافت چربی قهوه ایLarge for gestational age - بزرگ برای سن حاملگیSmall for gestational age - حاملگی در سنین پائینGestational diabetes mellitus - دیابت بارداریAdipose-derived stem cells - سلول های بنیادی حاصل از چربیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیuncoupling protein 1 - پروتئین جدا سازی 1Angiopoietin-like protein 8 - پروتئین مانند آنژیوپوئیتین 8WAT - چی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 178, December 2016, Pages 1-12
Journal: Translational Research - Volume 178, December 2016, Pages 1-12
نویسندگان
Bruno Martinez-Perez, Miriam Ejarque, Cristina Gutierrez, Catalina Nuñez-Roa, Kelly Roche, Rocio Vila-Bedmar, Mónica Ballesteros, Ibon Redondo-Angulo, Anna Planavila, Francesc Villarroya, Joan Vendrell, Sonia Fernández-Veledo, Ana MegÃa,