کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5685118 | 1597932 | 2016 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals
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کلمات کلیدی
FDAASCONIRALNDSLNBICGSLNSBRFire - آتشAln - آلنAmerican Society of Clinical Oncology - انجمن آمریکایی انکولوژی بالینیIndocyanine green - ایندوسیانین سبزAxillary lymph node dissection - جداسازی گره لنفاوی زیر بغلFood and Drug Administration - سازمان غذا و داروbody mass index - شاخص توده بدنBMI - شاخص توده بدنیMethylene blue - متیلن آبیNear-infrared - نزدیک مادون قرمزSignal-to-background ratio - نسبت سیگنال به پس زمینهSentinel lymph node biopsy - نمونه برداری از غدد لنفاوی نگهبانhematoxylin-eosin - هماتوکسیلین ائوزینSentinel lymph node - گره لنفاوی SentinelAxillary lymph node - گره لنفاوی زیر بغل
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Sentinel lymph node biopsy (SLNB) has become a standard of care to detect axillary lymph metastasis in early-stage breast cancer patients with clinically negative axillary lymph nodes. Current SLNB detection modalities comprising a blue dye, a radioactive tracer, or a combination of both have advantages as well as disadvantages. Thus, near-infrared fluorescence imaging using indocyanine green (ICG) has recently been regarded as a novel method that has generated interest for SLNB around the world. However, the lack of appropriate fluorescence imaging systems has hindered further research and wide application of this method. Therefore, we developed novel fluorescence image-guided resection equipment (FIRE) to detect sentinel lymph nodes (SLNs). Moreover, to compare the ICG fluorescence imaging method with the blue dye method and to explore the universal feasibility of the former, a different type of hospital study was conducted. Ninety-nine eligible patients participated in the study at 3 different types of hospitals. After subcutaneous ICG allergy testing, all the patients were subcutaneously injected with methylene blue and ICG into the subareolar area. Consequently, 276 SLNs (range 1-7) were identified in 98 subjects (detection rate: 99%) by using the ICG fluorescence imaging method. In contrast, the blue dye method only identified 202 SLNs (range 1-7) in 91 subjects (detection rate: 91.92%). Besides, the results of the fluorescence imaging method were similar in the 3 hospitals. Our findings indicate the universal feasibility of the ICG fluorescence imaging method for SLNB using the fluorescence image-guided resection equipment in early breast cancer detection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 178, December 2016, Pages 74-80
Journal: Translational Research - Volume 178, December 2016, Pages 74-80
نویسندگان
Kunshan He, Chongwei Chi, Deqiang Kou, Wenhe Huang, Jundong Wu, Yabing Wang, Lifang He, Jinzuo Ye, Yamin Mao, Guo-Jun Zhang, Jiandong Wang, Jie Tian,