کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5697267 1601058 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Le cancer de la prostate neuro-endocrine : histoire naturelle, caractéristiques moléculaires, prise en charge et perspectives
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Le cancer de la prostate neuro-endocrine : histoire naturelle, caractéristiques moléculaires, prise en charge et perspectives
چکیده انگلیسی
Neuroendocrine prostate cancer is a rare malignancy with a an adverse prognostic. Histologically, It can be pure (small cells or large cells neuroendocrine carcinoma) or mixed with a adenocarcinoma component. Rarely diagnosed de novo, neuroendocrine prostate cancer is generally associated with advanced stage disease resistant to castration. As such, this histological subtype could represent an aggressive evolution of prostatic adenocarcinoma, through the epithelio-neuroendocrine transdifferentiation mechanism (phenomenon of lineage plasticity). Nonetheless, neuroendocrine prostate cancer is a heterogeneous malignancy with multiple histopathological variants showing distinct clinical features. The broad variety of molecular analyses could help to understand the ontogeny of this histological subtype and its signaling pathways. This may also allow identifying diagnostic and prognostic biomarkers as well as potential molecular targets. However, treatment options are currently limited and consist only in platinium-based chemotherapy for advanced stage disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 104, Issue 9, September 2017, Pages 789-799
نویسندگان
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