کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5697464 | 1410308 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chimiothérapie à hautes doses comme stratégie pour contourner la résistance aux médicaments dans les tumeurs solides
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کلمات کلیدی
Solid tumors - تومورهای جامدTumeurs solides - تومورهای جامدGerm cell tumors - تومورهای سلول های بنیادیTumeurs germinales - تومورهای سلول های بنیادیOvarian cancer - سرطان تخمدانCancer de l’ovaire - سرطان تخمدانBreast cancer - سرطان پستانCancer du sein - سرطان پستانHigh-dose chemotherapy - شیمی درمانی با دوزهای بالاAutologous stem cell transplant - پیوند سلول های بنیادی اتولوگ
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
The concept of high-doses chemotherapy was developed in the 1980s based on in vitro scientific observations. Exposure of tumor cells to increasing concentrations of alkylating agents resulted in increased cell death in a strong dose-response manner. Moreover, the acquired resistance of tumor cells could be overcome by dose intensification. In clinic, dose intensification of alkylating agents resulted in increased therapeutic responses, however associated with significant hematological toxicity. Following the development of autologous stem cells transplantation harvesting from peripheral blood, the high-doses of chemotherapy, initially associated with marked toxic effects, could be more easily tolerated. As a result, the approach was evaluated in different types of solid tumors, including breast, ovarian and germ cell tumors, small cell lung carcinoma, soft tissue sarcomas and Ewing sarcoma. To date, high-doses chemotherapy with hematopoietic stem cells support is only used as a salvage therapy to treat poor prognosis germ cell tumors patients with chemo-sensitive disease. Regarding breast and ovarian cancer, high-doses chemotherapy should be considered only in the context of clinical trials. However, intensive therapy as an approach to overcome resistance to standard treatments is still relevant. Numerous efforts are still ongoing to identify novel therapeutic combinations and active treatments to improve patients' responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 103, Issue 10, October 2016, Pages 861-868
Journal: Bulletin du Cancer - Volume 103, Issue 10, October 2016, Pages 861-868
نویسندگان
Frédéric Selle, Joseph Gligorov, Daniele G. Soares, Jean-Pierre Lotz,