The role of DNA repair capacity in lung cancer risk among never-smokers: A systematic review of epidemiologic studies

Differential DNA repair capacity and DNA repair gene variation may explain some of the lung cancer risk among never-smokers. The number of studies to date are limited and many studies suffer from small sample size and there has been limited validation of findings. Methodological issues including tissue selection and standardizing lab techniques remain as barriers for evaluating DNA repair in population-based studies.