کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5697520 | 1601081 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Durable, exceptional response to temozolomide in a patient with extensive-stage small cell lung cancer (ES-SCLC) metastatic to brain
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Durable, exceptional response to temozolomide in a patient with extensive-stage small cell lung cancer (ES-SCLC) metastatic to brain Durable, exceptional response to temozolomide in a patient with extensive-stage small cell lung cancer (ES-SCLC) metastatic to brain](/preview/png/5697520.png)
چکیده انگلیسی
Small cell lung cancer (SCLC) is an aggressive tumor that is frequently metastatic at diagnosis. Unfortunately, the repertoire of agents available to clinicians tasked with treating relapsed or refractory extensive-stage SCLC (ES-SCLC) is limited. We report the case of a patient with extensive, relapsed brain metastases who had an exceptional initial response to temozolomide (TMZ). We describe also the ongoing, durable complete radiographic response in excess of four years achieved via a combination of long-term therapy with TMZ and selectively deployed stereotactic radiosurgery (SRS). In spite of its recent addition to the National Comprehensive Cancer Network (NCCN) guidelines for relapsed SCLC, TMZ remains underutilized for this indication. This case supports the off-label use of TMZ in relapsed SCLC, especially those with central nervous system (CNS) metastases--for whom there are few to no available treatment options.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment and Research Communications - Volume 10, 2017, Pages 17-20
Journal: Cancer Treatment and Research Communications - Volume 10, 2017, Pages 17-20
نویسندگان
Carl M. Gay, Patricia M. de Groot, M. Catherine Pietanza, Lauren Averett Byers,