کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5697620 1601104 2017 47 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The expanding role of immunotherapy
ترجمه فارسی عنوان
نقش گسترش ایمنوتراپی
کلمات کلیدی
بازدارنده های بازرسی، آگونیست های تحریک کننده درمان سلولی، واکسن ویروس، ترکیبی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی
The use of agents able to modulate the immune system to induce or potentiate its anti-tumour activity is not a new strategy in oncology. However, the development of new agents such as immune checkpoint inhibitors has achieved unprecedented efficacy results in a wide variety of tumours, dramatically changing the landscape of cancer treatment in recent years. Ipilimumab, nivolumab, pembrolizumab or atezolizumab are now standard of care options in several malignancies and new indications are being approved on a regular basis in different tumours. Moreover, there are many other novel immunotherapy strategies that are currently being assessed in clinical trials. Agonists of co-stimulatory signals, adoptive cell therapies, vaccines, virotherapy and others have raised interest as therapeutic options against cancer. In addition, many of these novel approaches are being developed both in monotherapy and as part of combinatory regimes in order to synergize their activity. The results from those studies will help to define the expanding role of immunotherapy in cancer treatment in a forthcoming future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 54, March 2017, Pages 74-86
نویسندگان
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