کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5702821 1410654 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell-free and circulating tumor cell-based biomarkers in men with metastatic prostate cancer: Tools for real-time precision medicine?
ترجمه فارسی عنوان
بیومارکرهای مبتنی بر سلول های تومور بدون سلول در مردان مبتلا به سرطان پروستات متاستاتیک: ابزار دقیق پزشکی در زمان واقعی؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی
The recent expansion of therapeutic options for the treatment of metastatic prostate cancer highlights the need for precision medicine approaches to enable the rational selection of appropriate therapies for individual patients. In this context, circulating biomarkers in the peripheral blood are attractive as readily accessible tools for predicting and monitoring therapeutic response. In the case of circulating tumor cells and circulating tumor DNA, they may also serve as a noninvasive means of assessing molecular aberrations in tumors at multiple time points before and during therapy. These so-called “liquid biopsies” can provide a snapshot view of tumor molecular architecture and may enable clinicians to monitor the molecular status of tumors as they evolve during treatment, thus allowing for individualized precision therapeutic decisions for patients over time. In this review, we outline recent progress in the field of circulating biomarkers in metastatic prostate cancer and evaluate their potential for enabling this vision of real-time precision medicine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urologic Oncology: Seminars and Original Investigations - Volume 34, Issue 11, November 2016, Pages 490-501
نویسندگان
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