کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5721820 1608101 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperEffects of omega-3 polyunsaturated fatty acids on psychophysiological symptoms of post-traumatic stress disorder in accident survivors: A randomized, double-blind, placebo-controlled trial
ترجمه فارسی عنوان
اثرات اسیدهای چرب غیر اشباع امگا 3 بر علائم روانشناختی اختلال استرس پس از سانحه در بازماندگان حادثه: یک کارآزمایی تصادفی، دو سو کور، کنترل پلاسبو
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- Heightened heart rate is known to be a prominent feature of PTSD.
- Omega-3 polyunsaturated fatty acids may prevent these physiological symptoms.
- We conducted a randomized, placebo-controlled trial of 83 Japanese accident survivors.
- Heart rate three months after the event was significantly lower in the omega-3 group.
- Omega-3 may be effective for secondary prevention of physiological symptoms of PTSD.

BackgroundPsychophysiological symptoms (e.g., pounding heart) are known to be a prominent feature of post-traumatic stress disorder (PTSD). Although omega-3 polyunsaturated fatty acids (PUFAs) have a beneficial potential pharmacological effect of preventing these psychophysiological symptoms, no clinical data is yet available. Therefore, we conducted a randomized, double-blind, placebo-controlled trial of Japanese accident survivors.MethodsA total of 83 participants received either omega-3 PUFAs (1470 mg docosahexaenoic acid and 147 mg eicosapentaenoic acid per day) or placebo within 10 days of the accidental injury. After 12-week supplementation, participants performed script-driven imagery of their traumatic event during monitoring of their heart rate and skin conductance.ResultsAnalysis revealed that heart rate during both rest and script-driven imagery was significantly lower in the omega-3 group than the placebo group, whereas baseline heart rate was comparable between the two groups.LimitationsThe present trial was conducted at a single-center in Japan and psychophysiological symptoms of PTSD in most participants were not serious.ConclusionThese findings suggest that post-trauma supplementation of omega-3 PUFAs might be effective for the secondary prevention of psychophysiological symptoms of PTSD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 224, 15 December 2017, Pages 27-31
نویسندگان
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