Research paperInternet delivered cognitive behavior therapy for antenatal depression: A randomised controlled trial

- Internet Cognitive Behavior Therapy (ICBT) is adapted for antenatal depression (AND).
- ICBT is found to reduce depressive symptoms more than regular maternity care.
- Efficacy, acceptability and utilization is comparable to regular ICBT.

Major depression occurs in 5-10% of pregnancies and is associated with many negative effects for mother and child, yet treatment options are scarce. To our knowledge, this is the first published randomised controlled trial on Internet delivered Cognitive Behavior Therapy (ICBT) for this group.ObjectiveTo test the efficacy of a pregnancy adapted version of an existing 10-week ICBT-program for depression as well as assessing acceptability and adherenceDesignRandomised controlled trial.SettingOnline and telephone.Population or sampleSelf-referred pregnant women (gestational week 10-28 at intake) currently suffering from major depressive disorder.Methods42 pregnant women (gestational week 12-28) with major depression were randomised to either treatment as usual (TAU) provided at their antenatal clinic or to ICBT as an add-on to usual care.Main outcome measuresThe primary outcome was depressive symptoms measured with the Montgomery-Åsberg depression rating scale-self report (MADRS-S). The Edinburgh Postnatal Depression Scale and measures of anxiety and sleep were used. Credibility, satisfaction, adherence and utilization were also assessed.ResultsThe ICBT group had significantly lower levels of depressive symptoms post treatment (p < 0.001, Hedges g =1.21) and were more likely to be responders (i.e. achieve a statistically reliable improvement) (RR = 0.36; p = 0.004). Measures of treatment credibility, satisfaction, utilization, and adherence were comparable to implemented ICBT for depression.LimitationsSmall sample size and no long-term evaluation.ConclusionPregnancy adapted ICBT for antenatal depression is feasible, acceptable and efficacious. These results need to be replicated in larger trials to validate these promising findings.