کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5731880 1611947 2016 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewIntraoperative modifiable risk factors of colorectal anastomotic leakage: Why surgeons and anesthesiologists should act together
ترجمه فارسی عنوان
بررسی عوامل خطرساز قابل تغییر در برون دهی آنستوموتیک کولورکتال: چرا جراحان و متخصصین بیهوشی باید با هم کار کنند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- There are many intraoperative risk factors of CAL which are modifiable by improvements in perioperative care.
- Multicenter registration study is necessary to determine the exact contribution of each intraoperative risk factor of CAL.
- Modifiable risk factors are: <36° Celsius, anemia, blood loss and transfusion, events and contamination, duration of surgery.
- Even in non-diabetes patients perioperative hyperglycemia increases the risk of CAL.
- Surgeons and anesthesiologists should cooperate in their continuous effort to reduce the number of CAL.

BackgroundColorectal anastomotic leakage (CAL) is a major surgical complication in intestinal surgery. Despite many optimizations in patient care, the incidence of CAL is stable (3-19%) [1]. Previous research mainly focused on determining patient and surgery related risk factors. Intraoperative non-surgery related risk factors for anastomotic healing also contribute to surgical outcome. This review offers an overview of potential modifiable risk factors that may play a role during the operation.MethodsTwo independent literature searches were performed using EMBASE, Pubmed and Cochrane databases. Both clinical and experimental studies published in English from 1985 to August 2015 were included. The main outcome measure was the risk of anastomotic leakage and other postoperative complications during colorectal surgery. Determined risk factors of CAL were stated as strong evidence (level I and II high quality studies), and potential risk factors as either moderate evidence (experimental studies level III), or weak evidence (level IV or V studies).ResultsThe final analysis included 117 articles. Independent factors of CAL are diabetes mellitus, hyperglycemia and a high HbA1c, anemia, blood loss, blood transfusions, prolonged operating time, intraoperative events and contamination and a lack of antibiotics. Unequivocal are data on blood pressure, the use of inotropes/vasopressors, oxygen suppletion, type of analgesia and goal directed fluid therapy. No studies could be found identifying the impact of body core temperature or mean arterial pressure on CAL. Subjective factors such as the surgeons' own assessment of local perfusion and visibility of the operating field have not been the subject of relevant studies for occurrence in patients with CAL.ConclusionBoth surgery related and non-surgery related risk factors that can be modified must be identified to improve colorectal care. Surgeons and anesthesiologists should cooperate on these items in their continuous effort to reduce the number of CAL. A registration study determining individual intraoperative risk factors of CAL is currently performed as a multicenter cohort study in the Netherlands.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 36, Part A, December 2016, Pages 183-200
نویسندگان
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