کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5731903 1611947 2016 9 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ResearchPrognostic value of alkaline phosphatase, gamma-glutamyl transpeptidase and lactate dehydrogenase in hepatocellular carcinoma patients treated with liver resection
ترجمه فارسی عنوان
تحقیقات اصلی: مقدار پروتئین آلکالین فسفاتاز، گاما گلوتامیل ترانسپپتیداز و لاکتات دهیدروژناز در بیماران مبتلا به سرطان کولورکتال، تحت درمان با رزکسیون کبد
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موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- The prognostic value of alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) and lactate dehydrogenase (LDH) have not been explored deeply and widely in surgically treated hepatocellular carcinoma (HCC) patients just like AFP.
- Our study was the first one to explore the prognosis value of ALP, GGT and LDH simultaneously in such patients and found that preoperative ALP, GGT and LDH could predict prognosis.
- We found that preoperative ALP, GGT and LDH could predict prognosis in such patients.

BackgroundAlkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) and lactate dehydrogenase (LDH) are routinely tested before surgery and are easily obtained. They are also the most widely used tumor markers, which have a certain reference value in the diagnosis of hepatocellular carcinoma (HCC). The prognostic values of ALP, GGT and LDH have not been explored deeply and few studies have investigated the prognosis value of them in surgically treated HCC patients. Our study was performed to verify the prognostic significance of preoperative ALP, GGT and LDH in hepatitis B virus (HBV)-related HCC patients receiving curative hepatectomy.Materials and methods469 pathologically confirmed HCC patients who received curative hepatectomy were retrospectively analyzed. Significant clinicopathological factors were collected and analyzed. Independent prognostic factors were identified by the multivariate analysis. Overall survival (OS) and recurrence-free survival (RFS) curves were analyzed and compared between different groups.ResultsPatients with low level of ALP, GGT and LDH have favorable OS and RFS, even in cirrhosis subgroup. ALP, GGT and LDH were also closely related to some important clinicopathological parameters. GGT and LDH were significant independent prognostic factors of both OS and RFS, while ALP was just a significant independent prognostic factor of OS, rather than RFS.ConclusionsPreoperative ALP, GGT and LDH could predict prognosis in HBV-related HCC patients who received curative liver resection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 36, Part A, December 2016, Pages 143-151
نویسندگان
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