کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5732091 | 1611940 | 2017 | 11 صفحه PDF | دانلود رایگان |
- To investigate the efficacy and safety between liposomal bupivacaine and standard bupivacaine in patients undergoing total knee arthroplasty.
- Only high quality studies were selected.
- Liposomal bupivacaine infiltration provides superior pain relief and less morphine consumption.
ObjectiveThis meta-analysis aimed to compare the efficacy and safety of intraoperative peri-articular liposomal bupivacaine and standard bupivacaine in patients undergoing total knee arthroplasty.MethodsA systematic search was performed in Medline (1966-2016.9), PubMed (1966-2016.9), Embase (1980-2016.9), ScienceDirect (1985-2016.9) and the Cochrane Library. Only high-quality studies were selected. Meta-analysis was performed using Stata 11.0 software.ResultsThree randomized controlled trials (RCTs) and two non-randomized controlled trials (Non-RCTs), including 1214 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between groups in terms of visual analogue scale (VAS) score at 24 h (SMD = â0.241, 95% CI: â0.374 to â0.108, P = 0.000), VAS score at 48 h (SMD = â0.124, 95% CI: â0.256 to 0.009, P = 0.0068), morphine equivalent consumption on POD 1 (SMD = â0.275, 95% CI: â0.398 to â0.153, P = 0.000) and incidence of nausea (RD = 0.038, 95% CI: 0.001 to 0.074, P = 0.042) and vomiting (RD = 0.38, 95% CI: 0.003 to 0.072, P = 0.032).ConclusionCompared to standard bupivacaine, intraoperative peri-articular liposomal bupivacaine infiltration promotes superior pain relief and less morphine consumption after total knee arthroplasty. In addition, there were fewer side effects associated with liposomal bupivacaine infiltration.
Journal: International Journal of Surgery - Volume 39, March 2017, Pages 238-248