کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5732091 1611940 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewComparison of peri-articular liposomal bupivacaine and standard bupivacaine for postsurgical analgesia in total knee arthroplasty: A systematic review and meta-analysis
ترجمه فارسی عنوان
بررسی مقایسه ای از بوپیواکائین لیپوزومی پروتئین مفصلی و بوپیواکائین استاندارد برای بیهوشی بعد از عمل جراحی در آرتروپلاستی کل زانو: بررسی منظم و متاآنالیز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- To investigate the efficacy and safety between liposomal bupivacaine and standard bupivacaine in patients undergoing total knee arthroplasty.
- Only high quality studies were selected.
- Liposomal bupivacaine infiltration provides superior pain relief and less morphine consumption.

ObjectiveThis meta-analysis aimed to compare the efficacy and safety of intraoperative peri-articular liposomal bupivacaine and standard bupivacaine in patients undergoing total knee arthroplasty.MethodsA systematic search was performed in Medline (1966-2016.9), PubMed (1966-2016.9), Embase (1980-2016.9), ScienceDirect (1985-2016.9) and the Cochrane Library. Only high-quality studies were selected. Meta-analysis was performed using Stata 11.0 software.ResultsThree randomized controlled trials (RCTs) and two non-randomized controlled trials (Non-RCTs), including 1214 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between groups in terms of visual analogue scale (VAS) score at 24 h (SMD = −0.241, 95% CI: −0.374 to −0.108, P = 0.000), VAS score at 48 h (SMD = −0.124, 95% CI: −0.256 to 0.009, P = 0.0068), morphine equivalent consumption on POD 1 (SMD = −0.275, 95% CI: −0.398 to −0.153, P = 0.000) and incidence of nausea (RD = 0.038, 95% CI: 0.001 to 0.074, P = 0.042) and vomiting (RD = 0.38, 95% CI: 0.003 to 0.072, P = 0.032).ConclusionCompared to standard bupivacaine, intraoperative peri-articular liposomal bupivacaine infiltration promotes superior pain relief and less morphine consumption after total knee arthroplasty. In addition, there were fewer side effects associated with liposomal bupivacaine infiltration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 39, March 2017, Pages 238-248
نویسندگان
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