کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5732262 1611939 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewEfficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis
ترجمه فارسی عنوان
بررسی اثربخشی و ایمنی ماتریکس پوستی در درمان زخم پای دیابتی: بررسی منظم و متاآنالیز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- Acelluar dermal matrix may accelerate the healing velocity of uninfected, non-ischemic, full-thickness diabetic foot ulcer.
- Compared with standard of care, the utility of acellular dermal matrix generates no more complications.
- Acellular dermal matrix is a promising method in treating refractory diabetic foot ulcer.

BackgroundDiabetic foot ulcer(DFU) is a chronic, refractory disease in need of multidisciplinary endeavour, miscellaneous strategies have been adopted to address this annoying issue, including acellular dermal matrix(ADM)/negative pressure wound therapy/standard of care (SOC) etc. However, consensus has not been reached. As a promising procedure, the efficacy and safety of ADM remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of acellular dermal matrix to standard of care in DFU.MethodsDatabases, including Pubmed, Medline, Embase and Cochrane library were searched to identify RCTs comparing ADM to SOC in DFU patients. The outcomes mainly included complete wound healing, mean time to heal and adverse events.ResultsA total of 632 DFU patients from 6 RCTs were subjected to meta-analysis. The results showed that compared with the merely SOC, the complete healing rate in ADM group was higher both at 12 weeks [risk ratio (RR) 2.31, 95% confidence interval (CI) 1.42 to 3.76] and 16 weeks [RR 1.57, 95% CI 1.28 to 1.93]. The mean time to complete wound healing was shorter in ADM group [MD = −2.98, 95% CI: −5.15 to −0.82]. The occurrence of adverse event in both groups showed no significant difference [RR 0.98, 95%CI 0.58 to 1.67].ConclusionCompared with standard of care, acellular dermal matrix may accelerate the healing velocity of uninfected, non-ischemic, full-thickness diabetic foot ulcer. Acellular dermal matrix showed superiority compared with standard of care alone, while generating no more complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 40, April 2017, Pages 1-7
نویسندگان
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