کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735920 | 1613076 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of early life stress on rodent hippocampal synaptic plasticity: a systematic review
ترجمه فارسی عنوان
اثرات استرس زودهنگام بر پلاستیک سیناپسی هیپوکامپ: یک بررسی سیستماتیک
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Early life stress shapes brain development and animal behavior. Neurophysiological properties such as signal transmission and synaptic plasticity are thought to underlie the animal's behavioral performance. We carried out a systematic review to determine how early life stress relates to neurophysiology in rodents. We specifically discuss effects on basal transmission and long-term potentiation in the hippocampus, as this brain area undergoes strong developmental changes during the first postnatal weeks. In general, basal transmission does not appear to be affected by early life conditions. Long-term potentiation is mainly increased by mild stress, while it is impaired by more severe early life stressors. The dentate gyrus shows stronger effects than the CA1 area. These changes may impact on hippocampus-dependent behavior. We conclude that rodent early life stress models provide important insights in stressor-dependent effects after human childhood adversity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Behavioral Sciences - Volume 14, April 2017, Pages 155-166
Journal: Current Opinion in Behavioral Sciences - Volume 14, April 2017, Pages 155-166
نویسندگان
Nienke AV Derks, Harm J Krugers, Casper C Hoogenraad, Marian Joëls, R Angela Sarabdjitsingh,