کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736642 | 1613782 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of caveolin-1/vascular endothelial growth factor pathway in basic fibroblast growth factor-induced angiogenesis and neurogenesis after treadmill training following focal cerebral ischemia in rats
ترجمه فارسی عنوان
نقش کانال رشد فاکتور رشد یبوست عروق کاورولین-1 / عصبی در آنژیوژنز ناشی از فاکتور رشد فیبروبلاستی و نوروژنز پس از آموزش تردمیل پس از ایسکمی کانونی مغزی در موش صحرایی
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کلمات کلیدی
NVUMCAOFGFECAshRNAbFGF5-bromo-2′-deoxyuridine - 5-bromo-2'-deoxyuridineBasic FGF - FGF پایهRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهsmall hairpin RNA - RNA کوچک موی سرAngiogenesis - آنژیوژنزmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیBrdU - بروموداکسی اوریدینTreadmill - تردمیلexternal carotid artery - شریان کاروتید خارجیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)fibroblast growth factor - فاکتور رشد فیبروبلاستNeurogenesis - نوروژنزneurovascular unit - واحد عصبی عضلانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats. Treadmill exercise was started 2Â days after ischemia-reperfusion in MCAO rats and continued until 7 or 28Â days after MCAO, after which the animals were sacrificed. Changes in neurological deficit, infarction volume, neuronal morphology, expression levels of bFGF, caveolin-1, and vascular endothelial growth factor (VEGF), and angiogenesis and neurogenesis in the ischemic penumbra were examined by reverse transcription-polymerase chain reaction, western blots, and/or double immunofluorescence. The results suggested that treadmill exercise promoted the expression of bFGF, improved neurological recovery, and reduced infarct volume compared with non-exercised rats, and also enhanced the expression of caveolin-1, VEGF, VEGF receptor 2(FIK-1)/CD34, and Brdu/nestin staining. Small interfering RNA targeting bFGF blocked the protective effects of bFGF. In addition, 4Â weeks of post-stroke recovery still ameliorated ischemia-induced damage without bFGF shRNA. These findings suggest a novel mechanism underlying the beneficial effects of bFGF following stroke, and indicate that treadmill exercise may aid stroke recovery by regulating the caveolin-1/VEGF pathway in the ischemic zone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1663, 15 May 2017, Pages 9-19
Journal: Brain Research - Volume 1663, 15 May 2017, Pages 9-19
نویسندگان
Qiongyi Pang, Huimei Zhang, Zhenzhen Chen, Yudan Wu, Min Bai, Yidian Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Chen,