کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737765 | 1614732 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn
ترجمه فارسی عنوان
اهداکننده اکسید نیتریک، ایزوسوربید دینیترات، باعث ایجاد حساسیت پوستی سفلی، همراه با حساسیت شاخ پشتی مدولاری
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NHSTriton XISDNNTGTrigeminalWDRMDHCGRPTBSERKRM ANOVA - ANOVA RMBSA - BSAbovine serum albumin - آلبومین سرم گاوrepeated measures analysis of variance - اندازه گیری های مکرر تجزیه و تحلیل واریانسIsosorbide dinitrate - ایزوسورباید دینیترافتTris-buffered saline - تریس بافر شورCentral sensitization - حساس شدن مرکزیPain - دردHeadache - سردردnormal horse serum - سرم طبیعی اسبmedullary dorsal horn - شاخ پشتی مدولارwide dynamic range - طیف گسترده ای پویاMigraine - میگرنNitroglycerin - نیتروگلیسیرینHyperalgesia - پردردی یا هایپرآلژزیcalcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونینextracellular signal-regulated kinases - کیناز های تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Nitric oxide donors are known to produce headache in healthy as well as migraine subjects, and to induce extracephalic cutaneous hypersensitivity in rodents. However, little is known on the effect of nitric oxide donors on cephalic cutaneous sensitivity. Combining behavioral, immunohistochemical, and in vivo electrophysiological approaches, this study investigated the effect of systemic administration of the nitric oxide donor, isosorbide dinitrate (ISDN), on cephalic and extracephalic cutaneous sensitivity and on neuronal activation within the medullary dorsal horn (MDH) in the rat. Systemic administration of ISDN increased selectively the first phase and interphase of the facial formalin test, but had no effect on the hindpaw formalin one. Monitoring neuronal activity within the MDH with phospho-ERK1/2 immunoreactivity revealed that ISDN alone did not activate MDH neurons, but significantly increased the number of formalin-evoked phospho-ERK1/2-immunoreactive cells in the ipsilateral, but not contralateral, MDH. Using in vivo electrophysiological unit recordings, we show that ISDN administration never affected the spontaneous activity of trigeminal wide dynamic range neurons, but, facilitated C-fiber-evoked responses in half the neurons tested. This research demonstrates that a nitric oxide donor, isosorbide dinitrate, induces selectively cephalic hyperalgesia that arises as a consequence of central sensitization in pain pathways that subserve meningeal nociception. This model better mimics the clinical condition and offers another possibility of studying the role of nitric oxide donor in the physiopathology of headache.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 157-166
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 157-166
نویسندگان
José MarÃa Flores Ramos, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, Radhouane Dallel,