کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738102 | 1615046 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Digitoxin increases sensitivity of glioma stem cells to TRAIL-mediated apoptosis
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کلمات کلیدی
IAPGSCsSensitization effectDigitoxinTNFApoptosis - خزان یاختهایCNS - دستگاه عصبی مرکزیGlioma stem cells - سلول های بنیادی گلیوماcentral nervous system - سیستم عصبی مرکزیtumor necrosis factor - فاکتور نکروز تومورTRAIL - قطارinhibitor of apoptosis protein - مهار کننده پروتئین آپوپتوزیسdeath receptor - گیرنده مرگ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Malignant glioma is one type of common malignancy in central nervous system (CNS) tumors which has a very bad influence on the survival quality of the patients. In this regard, lots of studies on improving the therapeutic effects of malignant glioma have been done continuously. This study takes glioma stem cells (GSCs) as the subject and focuses on the sensitization effect of digitoxin (DT) on the apoptosis mediated by TNF-related apoptosis-inducing ligand (TRAIL) to prove that the combination therapy of DT and TRAIL has a more active effect of inducing GSCs apoptosis. This study used cultured GSCs. Comparisons of single drug therapy and combination therapy indicated that DT had a synergistic action with TRAIL to produce a more active effect of inducing the apoptosis of GSCs. This effect was also shown in the changes of expressions of cell apoptosis pathway related protein markers tested by Western Blot method. In conclusion, DT had a sensitization effect on GSCs apoptosis mediated by TRAIL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 653, 13 July 2017, Pages 19-24
Journal: Neuroscience Letters - Volume 653, 13 July 2017, Pages 19-24
نویسندگان
Shang Zhixuan, Zhang Liwei,