کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738762 | 1615054 | 2017 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice
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کلمات کلیدی
ACTHCRFAMPAMC4HFSN-methyl-d-aspartateNMDAEPSP - epspiInfantile spasms - اسپاسم نوزادانα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکEpilepsy - بیماری صرعMemory consolidation - تثبیت حافظهhigh frequency stimulation - تحریک فرکانس بالاlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP corticotropin releasing factor - عامل آزاد کننده کورتیکوتروپینknock-out - ناک اوتwild-type - نوع وحشیadrenocorticotropic hormone - هورمون adrenocorticotropicHippocampus - هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
ACTH, a member of the melanocortin family of peptides, is often used in the treatment of the developmental epileptic encephalopathy spectrum disorders including, Ohtahara, West, Lennox Gastaut and Landau-Kleffner Syndromes and electrical status epilepticus of sleep. In these disorders, although ACTH is often successful in controlling the seizures and/or inter-ictal EEG abnormalities, it is unknown whether ACTH possesses other beneficial effects independent of seizure control. We tested whether ACTH can ameliorate the intrinsic impairment of hippocampal-based learning and memory in epileptic Kcna1-null (KO) mice. We found that ACTH â administered in the form of Acthar Gel given i.p. four times daily at a dose of 4 IU/kg (16 IU/kg/day) for 7Â days - prevented impairment of long-term potentiation (LTP) evoked with high-frequency stimulation in CA1 hippocampus and also restored spatial learning and memory on the Barnes maze test. However, with this treatment regimen, ACTH did not exert a significant effect on the frequency of spontaneous recurrent seizures. Together, our findings indicate that ACTH can ameliorate memory impairment in epileptic Kcna1-null mice separate from seizure control, and suggest that this widely used peptide may exert direct nootropic effects in the epileptic brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 645, 3 April 2017, Pages 14-18
Journal: Neuroscience Letters - Volume 645, 3 April 2017, Pages 14-18
نویسندگان
Morris H. Scantlebury, Kyoung-Chul Chun, Shun-Chieh Ma, Jong M Rho, Do Young Kim,