کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738843 1615061 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arhgef1 is expressed in cortical neural progenitor cells and regulates neurite outgrowth of newly differentiated neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Arhgef1 is expressed in cortical neural progenitor cells and regulates neurite outgrowth of newly differentiated neurons
چکیده انگلیسی
Neurite outgrowth is crucial for the maturation of neurons and the establishment of anatomical connections during development of the nervous system. We report here that Arhgef1, a RhoA guanine nucleotide exchange factor previously found expressed in the early stages of neuronal development to regulate neurite outgrowth, is also highly expressed in cortical neural progenitor cells (NPCs). To better dissect its role in NPCs, we knocked down Arhgef1 expression in these cells and induced differentiated of them into neurons. Notably, silencing of Arhgef1 markedly enhanced neurite outgrowth in neurons derived from NPCs. Furthermore, we showed that Arhgef1 silencing inhibited the activity of RhoA, and pharmacological blockade of RhoA activity promoted neurite outgrowth in NPC-derived neurons. These findings reveal that Arhgef1 controls the process of neurite formation in newborn cortical neurons derived from NPCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 638, 18 January 2017, Pages 27-34
نویسندگان
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