کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738843 | 1615061 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arhgef1 is expressed in cortical neural progenitor cells and regulates neurite outgrowth of newly differentiated neurons
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کلمات کلیدی
EGFFBSGEFbFGFRho GTPaseGAPDHRhoADAPICDC42Rac14′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولras homolog gene family, member A - ras homolog gene family، عضو ARas-related C3 botulinum toxin substrate 1 - زیر بغل سم بوتولینوم C3 مرتبط با ریز 1fetal bovine serum - سرم جنین گاوepidermal growth factor - عامل رشد اپیدرمیguanine nucleotide exchange factor - فاکتور تبادل نوکلئوتید گوانینbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهcell division control protein 42 - پروتئین کنترل تقسیم سلولی 42glyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Neurite outgrowth is crucial for the maturation of neurons and the establishment of anatomical connections during development of the nervous system. We report here that Arhgef1, a RhoA guanine nucleotide exchange factor previously found expressed in the early stages of neuronal development to regulate neurite outgrowth, is also highly expressed in cortical neural progenitor cells (NPCs). To better dissect its role in NPCs, we knocked down Arhgef1 expression in these cells and induced differentiated of them into neurons. Notably, silencing of Arhgef1 markedly enhanced neurite outgrowth in neurons derived from NPCs. Furthermore, we showed that Arhgef1 silencing inhibited the activity of RhoA, and pharmacological blockade of RhoA activity promoted neurite outgrowth in NPC-derived neurons. These findings reveal that Arhgef1 controls the process of neurite formation in newborn cortical neurons derived from NPCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 638, 18 January 2017, Pages 27-34
Journal: Neuroscience Letters - Volume 638, 18 January 2017, Pages 27-34
نویسندگان
Xiaoliang Xiang, Xiaoji Zhuang, Shengnan Li, Lei Shi,