کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5745752 1618781 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Perfluorooctane sulfonate impairs rat Leydig cell development during puberty
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Perfluorooctane sulfonate impairs rat Leydig cell development during puberty
چکیده انگلیسی


- Perfluorooctane sulfonate delays Leydig cell development during puberty.
- Perfluorooctane sulfonate disrupts Leydig cell specific gene expression.
- Perfluorooctane sulfonate promotes immature Leydig cell apoptosis.

Perfluorooctane sulfonate (PFOS) possibly delays male sexual development. However, its effects on pubertal Leydig cell development are unclear. The objective of the present study was to investigate the effects of in vivo PFOS exposure on rat Leydig cell development during puberty. Immature male Sprague Dawley rats were gavaged 5 or 10 mg/kg PFOS on postnatal day 35 for 21 days. Compared to the control (0 mg/kg), PFOS lowered serum testosterone levels without altering luteinizing hormone and follicle-stimulating hormone levels on postnatal day 56. PFOS in vivo downregulated mRNA or protein levels of Leydig cells (Lhcgr, Cyp11a1, and Cyp17a1). PFOS in vitro inhibited androgen secretion in immature Leydig cells at ≥ 50 nM, most possibly via downregulating Hsd17b3 mRNA level. At ≥ 500 nM, PFOS downregulated Lhcgr, inhibited BCL-2 and increased BAX levels to cause Leydig cell apoptosis. In conclusion, PFOS at a lower dose directly inhibited pubertal development of Leydig cells.

144

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 190, January 2018, Pages 43-53
نویسندگان
, , , , , , , , , ,