کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5752070 1619711 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human exposure to organic arsenic species from seafood
ترجمه فارسی عنوان
قرار گرفتن در معرض آلودگی به آرسنیک آلی از غذاهای دریایی
کلمات کلیدی
آرسنیک آلی، غذای دریایی، آرسنوسوگر، آرسنولیپید،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- Seafood is a major source of organic arsenic exposure.
- Arsenolipids and arsenosugars can be metabolized by humans.
- Some organic arsenic compounds and their metabolites can produce cytotoxic effects.
- Analytical standards for organic arsenic are a priority for advancing research.

Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be non-toxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet.In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volume 580, 15 February 2017, Pages 266-282
نویسندگان
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