کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5756251 | 1622550 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children
ترجمه فارسی عنوان
قرار گرفتن در معرض دیفنیل اتر دور ریوی و بعد از تولد و توانایی فضایی بصری در کودکان
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کلمات کلیدی
CDCPCBsCHAMACOSPBDEsNHANESVirtual Morris Water MazeNMDAN-methyl-d-aspartatestandard deviation - انحراف معیارNational Health and Nutrition Examination Survey - بررسی بهداشت و تغذیه ملیADHD - بیشفعالیPolychlorinated biphenyls - بیفنیل پلیکلر LOD یا Limit of detection - حد تشخیصPolybrominated diphenyl ethers - دیفنیل اتر پلی بوروندیPolybrominated diphenyl ether (PBDE) - دیفنیل اتر پلی بوریم (PBDE)limit of detection - محدودیت تشخیصCenters for Disease Control and Prevention - مراکز کنترل و پیشگیری از بیماریCenter for the Health Assessment of Mothers and Children of Salinas - مرکز ارزیابی سلامت مادران و کودکان سالیناسGeometric mean - میانگین هندسیAttention deficit/hyperactivity disorder - کمبود توجه / اختلال بیش فعالی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Polybrominated diphenyl ethers (PBDEs) are associated with impaired visual spatial abilities in toxicological studies, but no epidemiologic study has investigated PBDEs and visual spatial abilities in children. The Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine prenatal and childhood PBDEs and visual spatial abilities in 199 children. PBDEs were measured at 16±3 weeks gestation and at 1, 2, 3, 5, and 8 years using gas chromatography/isotope dilution high-resolution mass spectrometry. We used the Virtual Morris Water Maze to measure visual spatial abilities at 8 years. In covariate-adjusted models, 10-fold increases in BDE-47, â99, and â100 at 5 years were associated with shorter completion times by 5.2 s (95% Confidence Interval [CI] â9.3, â1.1), 4.5 s (95% CI â8.1, â0.9), and 4.7 s (95% CI â9.0, â0.3), respectively. However, children with higher BDE-153 at 3 years had longer completion times (β=5.4 s, 95% CI â0.3, 11.1). Prenatal PBDEs were associated with improved visual spatial memory retention, with children spending a higher percentage of their search path in the correct quadrant. Child sex modified some associations between PBDEs and visual spatial learning. Longer path lengths were observed among males with increased BDE-47 at 2 and 3 years, while females had shorter paths. In conclusion, prenatal and postnatal BDE-28, â47, â99, and â100 at 5 and 8 years were associated with improved visual spatial abilities, whereas a pattern of impairments in visual spatial learning was noted with early childhood BDE-153 concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 153, February 2017, Pages 83-92
Journal: Environmental Research - Volume 153, February 2017, Pages 83-92
نویسندگان
Ann M. Vuong, Joseph M. Braun, Kimberly Yolton, Changchun Xie, Glenys M. Webster, Andreas Sjödin, Kim N. Dietrich, Bruce P. Lanphear, Aimin Chen,