کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
576056 | 1453064 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo model
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo model A comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo model](/preview/png/576056.png)
چکیده انگلیسی
This study planned to determine the range of biological effects associated with ZnO-NP exposure using Drosophila melanogaster as an in vivo model. In addition, ZnCl2 was used to determine the potential role of Zn ions alone. Toxicity, internalization through the intestinal barrier, gene expression changes, ROS production, and genotoxicity were the end-points evaluated. No toxicity or oxidative stress induction was observed in D. melanogaster larvae, whether using ZnO-NPs or ZnCl2. Internalization of ZnO-NPs through the intestinal barrier was observed. No significant changes in the frequency of mutant clones (wing-spot test) or percentage of DNA in tail (comet assay) were observed although significant changes in Hsp70 and p53 gene expression were detected. Our study shows that ZnO-NPs do not induce toxicity or genotoxicity in D. melanogaster, although uptake occurs and altered gene expression is observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 296, 15 October 2015, Pages 166-174
Journal: Journal of Hazardous Materials - Volume 296, 15 October 2015, Pages 166-174
نویسندگان
Mohamed Alaraby, Balasubramanyam Annangi, Alba Hernández, Amadeu Creus, Ricard Marcos,