کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
576487 1453078 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Examination of the kinetics of degradation of the antineoplastic drug 5-fluorouracil by chlorine and bromine
ترجمه فارسی عنوان
بررسی سینتیک تخریب داروهای ضدویروسی 5-فلوروآوراوسیل توسط کلر و بروم
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بهداشت و امنیت شیمی
چکیده انگلیسی
This study examined the degradation of the widely used antineoplastic drug 5-fluorouracil (5FU) by chlorine and bromine. 5FU was determined to interact readily with free chlorine and bromine but was stable in the presence of chloramine. The removal of 5FU followed a second-order kinetic pattern. Apparent rates (kapp) of 5FU removal by chlorine and bromine were strongly pH dependent and had maximum 14.8 M−1 s−1 and 1.9 × 103 M−1 s−1kapp values, respectively at pH 7. Modeling of the dependence of the kapp values vs. pH indicated the presence of a relatively acidic (pK 6.4 vs. 8.5 of 5FU per se) 5FU intermediate generated in the presence of halogen species. Spectrophotometric measurements confirmed the increased acidity of 5FU chlorination products and allowed proposing a degradation pathway of 5FU by chlorine. This pathway suggests that 5FU chlorination proceeds via chlorine incorporation at the 6th carbon in the heterocyclic ring of 5FU.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 282, 23 January 2015, Pages 125-132
نویسندگان
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