Degradation of estrogens by laccase from Myceliophthora thermophila in fed-batch and enzymatic membrane reactors

► Estrogen removal was optimized in fed-batch bioreactors by evaluating the effect of the main process parameters. ► An enzyme membrane bioreactor (EMR) was proposed for the continuous degradation of estrogens. ► Estrone was degraded up to 95% and estradiol was not detected in the effluent of the EMR under steady state conditions. ► The residual estrogenic activity of the effluent was largely reduced up to 97%.