کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
579756 | 877826 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PCB congeners induced mitochondrial dysfunction in Vero cells
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
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چکیده انگلیسی
Two PCB congeners were assessed for their cytotoxicity on Vero cells, in the attempt to compare their structure-activity relationship and to investigate the role of mitochondria involved in toxicity. Flow cytometry was used to monitor the changes of mitochondrial membrane potential (ÎÏm), cell size and apoptosis rate. Treatments of Vero cell cultures with both PCB 126 and PCB 153 resulted in loss of cell viability in our experimental conditions. In ortho-substituted PCB 153 treated cells, loss of cell viability was accompanied by decreased ÎÏm and cell shrinkage. The coplanar congener, PCB 126, had no significant effects on ÎÏm or cell size in this time period of exposure. These studies showed that PCB 153 is more toxic than coplanar PCB 126 to Vero cells within 24Â h exposure. The cytotoxicity mechanism caused by coplanar or non-coplanar PCB congener was different, and apoptosis might be the main cell death pathway in PCB 153 treated cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 185, Issue 1, 15 January 2011, Pages 24-28
Journal: Journal of Hazardous Materials - Volume 185, Issue 1, 15 January 2011, Pages 24-28
نویسندگان
Kaili Shen, Chaofeng Shen, Jie Yu, Chunna Yu, Lei Chen, Dezhi Shi, Yingxu Chen,