کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5802159 1555656 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccination against canine leishmaniosis increases the phagocytic activity, nitric oxide production and expression of cell activation/migration molecules in neutrophils and monocytes
ترجمه فارسی عنوان
واکسیناسیون در برابر لیشمانیوز سگ باعث افزایش فعالیت فاگوسیتیک، تولید اکسید نیتریک و بیان مولکول های فعال / سلولی در نوتروفیل ها و مونوسیت ها می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


- The use of a canine protective vaccine would be an important control tool to canine leismaniosis.
- The vaccination employing Leishmune® induces in neutrophils and monocytes increase in phagocytic activity and NO production.
- The vaccination induces increased expression of TLR in neutrophils and monocytes from dogs.
- The vaccination induces preferentially inflammatory profile of cytokines.

Visceral leishmaniasis (VL) is transmitted by phlebotomine sandfly vectors and domestic dogs serve as a reservoir. The elimination of seropositive dogs has been a recommended strategy for managing the disease in Brazil. A protective canine vaccine would be an important tool for controlling the disease, reducing the parasites available to sandfly vectors and, consequently, reducing the number of human VL cases. Leishmune® is an anti-canine Leishmaniosis (VL Canine) vaccine produced by Zoetis (Pfizer, Brazil) that was commercially available in Brazil until 2014. The main goal of the present study was to investigate the protective immunological events induced by vaccination with Leishmune® in the time frame of one year. Healthy, non-vaccinated dogs and dogs of 1, 6 and 10 months post-vaccination were evaluated. Results showed that Leishmune® induced an increase in phagocytic activity of neutrophils and monocytes and also increased NO production. Immunological events were correlated with functional responses, as high levels of IgG and an increase of the receptor Fcγ were detected. Vaccination induced an increased expression of TLR (2, 4, 5, 9), integrin (CD29, CD49f), activation (MHCII) and co-stimulatory (CD80, CD81) molecules by neutrophils and monocytes. Vaccination led to decrease of IL-4 and an increase of IL-8 production by monocytes and higher IFN-γ and IL-17 production by T-cells. The results suggested that Leishmune® was able to induce a long-lasting change in immune response, mediated by supportive immunological events that may be participating in protective immunity against CL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 220, 15 April 2016, Pages 33-45
نویسندگان
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