کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5803880 | 1555695 | 2013 | 9 صفحه PDF | دانلود رایگان |

Ichthyophthirius multifiliis (Ich) is an important ectoparasitic ciliate that parasitizes gills and skin of freshwater fish resulting in massive mortality of fish. Currently there is no chemotherapeutant available to treat Ich effectively and economically. There is an urgent need to discover effective and safe parasiticides to control ichthyophthiriasis. In this study, anti-Ich efficacy of pentagalloylglucose, a compound extracted from the plant Galla chinensis was evaluated and the toxicity of the compound on channel catfish was determined. Pentagalloylglucose can kill all theronts at concentrations of 2.5-20Â mg/L during 5.6-233.9Â min and terminate reproduction of tomonts at 40Â mg/L. Pentagalloylglucose significantly reduced infective ability of theronts at 1, 2 and 5Â mg/L. The survival of naive channel catfish was 70% when treated with 10Â mg/L and 100% when treated with 20Â mg/L of pentagalloylglucose. For Ich infected catfish, the survival was 53.3% when treated with 10Â mg/L and 93.3% when treated with 20Â mg/L of pentagalloylglucose. Pentagalloylglucose at 20Â mg/L was effective for treating Ich infected catfish or preventing naive catfish from Ich infestation. Median lethal concentration of the compound to catfish was 151.3Â mg/L, which was 5 times the median effective concentration (30.5Â mg/L) for killing tomonts. The compound killed Ich by destroying the plasma membrane of the parasite. The result demonstrated pentagalloylglucose as a safe, effective potential parasiticide against I. multifiliis.
Journal: Veterinary Parasitology - Volume 198, Issues 1â2, 15 November 2013, Pages 45-53