کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5806430 | 1555779 | 2007 | 6 صفحه PDF | دانلود رایگان |

The plasma kinetics disposition of moxidectin following a subcutaneous administration with a long-acting formulation (Cydectin® 10%, Fort Dodge Animal Health, France) at the recommended dose of 1 mg kgâ1 body weight was evaluated in Charolais cattle breed (five females weighing 425-450 kg) for 120 days. Furthermore, its concentration was measured in hair for the same period. After plasma extraction and derivatization, samples were analysed by HPLC with fluorescence detection. Moxidectin was first detected at 1 h after treatment for plasma (2.00 ± 1.52 ng mlâ1) and at 2 days for hair (446.44 ± 193.26 ng gâ1). The peak plasma concentration (Cmax) was 55.71 ± 15.59 ng mlâ1 and 444.44 ± 190.45 ng gâ1 for plasma and hair, respectively. The mean calculated time of peak occurrence (Tmax) was 3.40 ± 3.36 and 2 days for plasma and hair, respectively. The mean residence time (MRT) was 28.93 ± 2.87 and 13.32 ± 2.48 days for plasma and hair cattle. The area under concentration-time curve (AUC) was 1278.95 ± 228.92 ng day mlâ1 and 2663.82 ± 1096.62 ng day gâ1 for plasma and hair, respectively. At the last sampling time (120 days), the concentration was 1.91 ± 0.26 ng mlâ1 and 0.69 ± 0.52 ng gâ1 for plasma and hair, respectively. The bioavailability of this long-acting formulation of moxidectin is similar to that registered after subcutaneous administration of moxidectin in cattle at 0.2 mg kgâ1 body weight. For the first time the moxidectin pharmacokinetics parameters in hair after a subcutaneous administration was described. The moxidectin profile concentrations in hair reflected that registered in plasma. The previous studies of efficacy have to be correlated to the extended period of absorption and distribution by the LA formulation due to the fivefold higher dose rate in comparison with the 1% injectable formulation (0.2 mg kgâ1 body weight).
Journal: Veterinary Parasitology - Volume 147, Issues 3â4, 20 July 2007, Pages 252-257