کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5810110 | 1556208 | 2013 | 9 صفحه PDF | دانلود رایگان |
In recent years the use of solid lipid nanoparticles (SLNs) as transport systems for the delivery of drugs and biomolecules has become particularly important. The use of cationic SLNs developed by the technique of microemulsion, which are complexed with DNA in order to study their application as non-viral vectors in gene therapy, is reported. The nanoparticles are characterized by scanning electron microscopy and transmission electron microscopy (SEM and TEM), atomic force microscopy (AFM) and differential scanning calorimetry (DSC). Furthermore, the process of lyophilization of the samples and their stability was studied. The nanoparticles obtained presented a particle size of 340Â nm with a positive surface charge of 44Â mV and the capability of forming lipoplexes with DNA plasmids was stated.
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Journal: European Journal of Pharmaceutical Sciences - Volume 49, Issue 2, 13 May 2013, Pages 157-165