Research paperEffects of Elaeagnus angustifolia L. powder supplementation on serum total antioxidant capacity and malondialdehyde levels in females with knee osteoarthritis

AimThe present study aimed to determine the effects of Elaeagnus angustifolia L. supplement on serum antioxidant status in females with knee osteoarthritis.MethodsIn this 8-week randomized clinical trial, 90 females with knee osteoarthritis were randomly assigned to one of three groups-medulla powder (15 g medulla powder), whole fruit powder (15 g whole fruit powder) or placebo. Information on dietary intake was collected using 24-h recall method for 3 days (one weekend day included). The serum levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) were measured using the Randox® assay and the fluorometry method respectively. Paired sample t-test, ANOVA and ANCOVA were used for statistical analysis.ResultsThe mean serum TAC level in the medulla, whole fruit and placebo groups increased from 1.12 ± 0.34 to 1.28 ± 0.27, 1.30 ± 0.28 to 1.50 ± 0.28 and 1.18 ± 0.19 to 1.30 ± 0.22 mmol/L respectively. In terms of the TAC level, the significant increase was only observed in the whole fruit group (P = 0.001). The mean serum MDA level in the medulla, whole fruit and placebo groups decreased from 3.80 ± 0.33 to 3.30 ± 0.41, 3.25 ± 0.51 to 2.45 ± 0.43 and 3.38 ± 0.63 to 2.56 ± 0.41, respectively. A statistically significant reduction was observed only in the whole fruit group (P = 0.009).DiscussionBased on the results, E. angustifolia L. in the form of whole fruit had beneficial effects on serum TAC and MDA levels in females with knee OA. This may show a possible disease modifying effect of E. angustifolia L. in knee osteoarthritis.