کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5813662 | 1556619 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference
ترجمه فارسی عنوان
گیرنده فاکتور 1 آزاد کننده کورتیکوتروپین، فعالیت سیستم پاداش را که منجر به ترجیح محل مضر شده ناشی از مورفین شده است، میانجی می کند
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کلمات کلیدی
CP-154,526CRF1RHypothalamus pituitary adrenal axisCPPNACDMHCRFTweenOXAPFABNSTVTARIACeA - CEAorexin A - اورکسین AOrexins - اورکسین هاconditioned place preference - ترجیح محل موظف استradioimmunoassay - رادیوایمونواسیcorticotrophin releasing factor - عامل آزاد کننده کورتیکوتروپینlocus coeruleus - لوکوس سیرولئوسPVN - مالیات بر ارزش افزودهHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالperifornical area - منطقه پرایفنیکmorphine - مورفینventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbensbed nucleus of the stria terminalis - هسته تخت ترمینال های استریcentral nucleus of the amygdala - هسته مرکزی آمیگدالparaventricular nucleus - هسته پروژسترویکdorsomedial hypothalamus - هیپوتالاموس dorsomediallateral hypothalamus - هیپوتالاموس جانبیcatecholamine - کاتکولآمینهاhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراCorticosterone - کورتیکوسترونGlucocorticoids - گلوکوکورتیکوئیدها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Different neurotransmitter systems are involved in behavioural and molecular responses to morphine. The brain stress system is activated by acute administration of drugs of abuse, being CRF the main neuropeptide of this circuitry. In this study we have studied the role of CRF1R in the rewarding effects of morphine using the CPP paradigm. For that, animals were treated with a CRF1R antagonist (CP-154,526) or vehicle during 6 days. Thirty min after receiving the antagonist, mice were injected with morphine on the same days that CP-154,526 was administered; another group received saline on the same days that vehicle was administered, and both groups were immediately conditioned. Control animals received vehicle and saline every day. On day 7, animals were tested for morphine-induced CPP. c-Fos, TH and OXA immunohistochemistry, NA turnover (HPLC), and corticosterone plasma concentration (RIA) were evaluated. Administration of a CRF1R antagonist CP-154,526 blocked the morphine-induced CPP and the increased NA turnover in the NAc in morphine-paired mice. CP-154-526 antagonised the enhancement in c-Fos expression evoked by morphine-induced CPP in the VTA and NAc, and the activation of the orexinergic neurons in the LLH. Present work demonstrates that morphine-induced CPP activates different brain areas involved in reward, and points out a critical role of CRF1R in molecular changes involved in morphine-conducted behaviours. Thus, our study supports a therapeutic potential of CRF1R antagonists in addictive disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 95, August 2015, Pages 168-180
Journal: Neuropharmacology - Volume 95, August 2015, Pages 168-180
نویسندگان
M. Carmen Lasheras, M. Luisa Laorden, M. Victoria Milanés, Cristina Núñez,