Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons

► Cocaine depolarizes LHb neurons and accelerates their ongoing firing. ► Cocaine enhances glutamate excitatory transmission. ► Dopamine, D1, D2 agonists, dopamine reuptake blocker mimicked cocaine's effect. ► Both D1 and D2 antagonists blocked cocaine's effects on EPSCs.