Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression

► Synaptic transmission in CCL2-transgenic mice is similar to non-transgenic mice. ► CCL2 protects against the depressing effects of ethanol on synaptic plasticity. ► CCL2 protects against ethanol induced learning impairments in fear conditioning.