کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5815155 1556646 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quercetin protects against the Aβ25-35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Quercetin protects against the Aβ25-35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU
چکیده انگلیسی

Quercetin has demonstrated protective effects against Aβ-induced toxicity on both neurons and endothelial cells. However, whether or not quercetin has an effect on the neurovascular coupling is unclear. In the present study, we aim to investigate the anti-amnesic effects of quercetin and to explore the underlying mechanisms. Aβ25-35 (10 nmol) was administrated to mice i.c.v. Quercetin was administrated orally for 8 days after injection. Learning and memory behaviors were evaluated by measuring spontaneous alternation in Morris Water Maze test and the step-through positive avoidance test. The regional cerebral blood flow was monitored before the Aβ25-35 injection and on seven consecutive days after injection. Mice were sacrificed and cerebral cortices were isolated on the last day. The effects of quercetin on the neurovascular unit (NVU) integrity, microvascular function and cholinergic neuronal changes, and the modification of signaling pathways were tested. Our results demonstrate that quercetin treatment for Aβ25-35-induced amnesic mice improved the learning and memory capabilities and conferred robust neurovascular coupling protection, involving maintenance of the NVU integrity, reduction of neurovascular oxidation, modulation of microvascular function, improvement of cholinergic system, and regulation of neurovascular RAGE signaling pathway and ERK/CREB/BDNF pathway. In conclusion, in Aβ25-35-induced amnesic mice, optimal doses of quercetin administration were beneficial. Quercetin protected the NVU likely through reduction of oxidative damage, inactivation of RAGE-mediated pathway and preservation of cholinergic neurons, offering an alternative medication for Alzheimer's disease.

► Quercetin showed multiple protective effects on cholinergic neurons induced by Aβ. ► Quercetin played a pivotal role in molecular cascades of the BBB induced by Aβ. ► Quercetin affected RAGE-mediated pathways in the cerebral neurovascular unit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 67, April 2013, Pages 419-431
نویسندگان
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