Keywords: پتید بتا آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β peptide; APP; amyloid precursor protein; BACE1; β-amyloid cleavage enzyme 1, β-secretase 1; GSM; gamma secretase modulator; LHS; left hand side; NSAID; non-steroidal anti-inflammatory drug; SAR; structure activ
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Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; AD; Alzheimerʹs Disease; ALS; amyotrophic lateral sclerosis; Amb; Amphotericin B; BBB; blood-brain barrier; CJD; Creutzfeld Jakob disease; CSF; cerebral spinal fluid; DCS; D-Cycloserine; DOX; Doxorubicin; GA; Geldanamycin; GAPDH;
Keywords: پتید بتا آمیلوئید; AMPA; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BDNF; brain derived neurotrophic factor; BF; basal forebrain; CGA; chromogranin A; CNS; central nervous system
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; Transthyretin; Proteolysis; Neuroprotection;
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; AD; Alzheimer's disease; Astr; amygdalostrial transition area; BBB; blood-brain barrier; BL; basolateral amygdala; c48/80; compound 48/80; CPu; caudate putamen; Den; dorsal endopiriform nucleus; DG; dentate gyrus; GI; gastrointe
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Immunotherapy; Vaccine; Monoclonal antibodies; Biomarkers; Amyloid β peptide; Maladie d'Alzheimer; Immunothérapie; Vaccin; Anticorps monoclonaux; Biomarqueurs; Peptide β amyloïde;
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; AFM; atomic force microscopy; CD; circular dichroism; CR; Congo red; FTIR; Fourier transform infrared; SDSL-EPR; site-directed spin labeling coupled to electron paramagnetic resonance; SSNMR; solid-state nuclear magnetic resonance
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; AD; Alzheimer's disease; HBSS; HEPES-buffered salt solution; ROS; reactive oxygen species; α7 nAChRs; α7-type nicotinic acetylcholine receptors; AchRabs; affinity purified antibodies to synthetic fragment 173-193 of the α7-su
Inhibitory effects of Tabernaemontana divaricata root extract on oxidative stress and neuronal loss induced by amyloid β25-35 peptide in mice
Keywords: پتید بتا آمیلوئید; Amyloid β peptide; Tabernaemontana divaricata; Oxidative stress; Memory impairment; Neuroprotection;
Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; Aβ immunotherapy; Complement; Complement receptor 1; Macrophage; Erythrocyte; Blood; Human;
Stoichiometric Zn2+ interferes with the self-association of Aβ42: Insights from size distribution analysis
Keywords: پتید بتا آمیلوئید; Amyloid β peptide; Zinc ions; Aggregation; Sedimentation velocity; Analytical ultracentrifugation;
Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?
Keywords: پتید بتا آمیلوئید; Oxidative stress (OS); Delta opioid receptor (DOR); Poly (ADP-ribose)-polymerase1 (PARP1); Neuroprotection; Attenuation; OS; Oxidative stress; DOR; Delta opioid receptor; PARP; Poly (ADP-ribose)-polymerase; AD; Alzheimer's disease; PD; Parkinson's disease
Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease
Keywords: پتید بتا آمیلوئید; ACh; acetylcholine; AD; Alzheimer's disease; Aβ; amyloid β peptide; [Ca2+]c; cytosolic Ca2+; CALHM1; Ca2+ homeostasis modulator-1 channel; FBS; fetal bovine serum; Mem; memantine; NCLX; mitochondrial Na±/Ca2+ exchanger; NFT; neurofibrillary tangles;
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; BACE1; IL-6; Oxidative stress; Phloroglucinol; TNF-α;
Short CommunicationsFIDA automation yields sub-femtomolar limit of detection for Aβ aggregates in body fluids
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; Diagnostic biomarker; Surface-based fluorescence intensity distribution analysis (sFIDA); Silica nanoparticles; Automation;
Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; anMan; anhydromannose; APP; amyloid precursor protein; β-CTF; C-terminal fragment of APP generated by β-cleavage; γ-CTF; C-terminal fragment of APP generated by γ-cleavage; CYB561A3; A3 variant of cytochrome b561; GAG; glycosa
An UHPLC-MS/MS method for simultaneous quantification of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid using micro-elution solid phase extraction
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β Peptide; UHPLC-MS/MS; Simultaneous quantification; Human cerebrospinal fluid;
Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; Complement; Complement receptor 1; Immune adherence; Blood; Erythrocyte; Human;
A new procedure for amyloid β oligomers preparation enables the unambiguous testing of their effects on cytosolic and mitochondrial Ca2+ entry and cell death in primary neurons
Keywords: پتید بتا آمیلوئید; Calcium; Mitochondria; Alzheimer's disease; Amyloid β peptide; Oligomers;
Complicated function of dopamine in Aβ-related neurotoxicity: Dual interactions with Tyr10 and SNK(26-28) of Aβ
Keywords: پتید بتا آمیلوئید; Amyloid β peptide; Dopamine; Binding; Fibril; Cytotoxicity;
The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; Aβ1-42A2V; amyloid β peptide 1-42 containing A673V mutation; Aβ1-42MIX; equimolar mixture of Aβ1-42wt and Aβ1-42A2V oligomers; Aβ1-42wt; amyloid β peptide 1-42 wild-type; AD; Alzheimer disease; C. elegans; Caenorhabditis el
Ginsenoside Rd attenuates Aβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons
Keywords: پتید بتا آمیلوئید; Ginsenoside Rd; Amyloid β peptide; Oxidative stress; Apoptosis; Hippocampal neurons;
Oleic acid ameliorates Aβ-induced inflammation by downregulation of COX-2 and iNOS via NFκB signaling pathway
Keywords: پتید بتا آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β peptide; APP; amyloid peptide precursor; β-secretase; BACE1; ROS; reactive oxygen species; COX-2; cyclooxygenase; iNOS; inducible nitric oxide synthase; NF-κB; nuclear factor-κB; MAPK; mitogen-activated protein
Increased Alzheimer's disease-like pathology in the APP/ PS1ÎE9 mouse model lacking Nrf2 through modulation of autophagy
Keywords: پتید بتا آمیلوئید; Amyloid precursor protein (APP); Amyloid β peptide; p62/SQSTM; mTOR pathway; Autophagy;
Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner
Keywords: پتید بتا آمیلوئید; MKDJXHKXBGDNQO-SIQRNXPUSA-N; Alzheimer's disease; Amyloid β peptide; Analytical ultracentrifugation; O-Acyl isopeptide; O-to-N intramolecular acyl migration;
Design and synthesis of an aminopiperidine series of γ-secretase modulators
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; γ-Secretase modulator; γ-Secretase inhibitor; Amyloid β peptide; Piperidine;
Estrogen receptor α promotes non-amyloidogenic processing of platelet amyloid precursor protein via the MAPK/ERK pathway
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; APP; amyloid precursor protein; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease domain; BBB; blood brain barrier; ERα; estrogen receptor α; α-ERKO; estrogen receptor α knock-out; ERK; extracellular-signal-re
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: پتید بتا آمیلوئید; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
Involvement of TRPV4 channels in Aβ40-induced hippocampal cell death and astrocytic Ca2+ signalling
Keywords: پتید بتا آمیلوئید; AA; arachidonic acid; Aβ; amyloid β peptide; BSO; buthionine sulfoximine; GFAP; glial fibrillary acidic protein; GSH; reduced glutathione; MAFP; methyl arachidonyl fluorophosphonate; MAP2; microtubule associated protein-2; PI; propidium iodide; PLA2; ph
A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide
Keywords: پتید بتا آمیلوئید; Aβ; amyloid β peptide; AD; Alzheimer's disease; DIC; N,Nâ²-diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; FAM; carboxyfluorescein; HOBt; N-hydroxybenzotriazole; HPLC; high-performance liquid chromatography; kDa; kiloda
Quercetin protects against the Aβ25-35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; The blood-brain barrier; The neurovascular unit; The receptor for advanced glycation end products; Aβ; amyloid β; AD; Alzheimer's disease; AChE; acetylcholinesterase; BBB; blood-brain barrier; BDNF; brain der
Na+ and K+ ion imbalances in Alzheimer's disease
Keywords: پتید بتا آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β peptide; CAβ42; levels of Aβ 1-42 peptide in CSF; Cb; cerebellum; CDR; clinical dementia rating; CSF; cerebrospinal fluid; FC; frontal cortex; MRI; magnetic resonance imaging; PC; parietal cortex; PIB; results
Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons
Keywords: پتید بتا آمیلوئید; Amyloid β peptide; Medial septum; Theta oscillations; Glutamatergic neurons; Cholinergic neurons; GABAergic neurons; M-current; A-current;
Structural and functional characterization of H2 haplotype MAPT promoter: Unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease
Keywords: پتید بتا آمیلوئید; AD; Alzheimer's disease; AP; activator protein; APOE; apolipoprotein E gene; APP; amyloid β peptide precursor gene; Aβ; amyloid β peptide; bp; base-pair; C/EBP; CCAAT/enhancer binding protein; C6; rat glioblastoma cells; CAT; chloramphenicol acetyltran
Research reportTargeting the neurovascular unit: Development of a new model and consideration for novel strategy for Alzheimer's disease
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; Blood-brain barrier; Cerebral microvascular endothelial cells; Neurovascular unit;
Diagnostic biologique de la maladie d'Alzheimer : avancées, limites et perspectives
Keywords: پتید بتا آمیلوئید; Maladie d'Alzheimer; Marqueurs biologiques; Peptide β-amyloïde; Protéine Tau; Diagnostic; Alzheimer's disease; Biological markers; Amyloid β peptide; Tau protein; Diagnosis;
Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits
Keywords: پتید بتا آمیلوئید; Ovariectomy; Alzheimer's disease; BACE; Amyloid β peptide; Phosphorylated-tau;
Green tea catechins prevent cognitive deficits caused by Aβ1-40 in rats
Keywords: پتید بتا آمیلوئید; 0.0% PE group; rats administered with water only; 0.5% PE group; rats administered with 5 g/L of PE; Aβ; amyloid β peptide; Aβ group; amyloid β peptide1-40-infused rats; AD; Alzheimer's disease; ANOVA; analysis of variance; APP; amyloid precursor pr
C1q binding and complement activation by prions and amyloids
Keywords: پتید بتا آمیلوئید; Alzheimer; Amyloid; C1q; Prion; Scrapie; Transmissible spongiform encephalopathy; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BSE; bovine spongiform encephalopathy; CJD; Creutzfeld-Jacob disease; FBD; familial Briti
Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid β-infused rats relates to the decreases of amyloid β and cholesterol levels in detergent-insoluble membrane fractions
Keywords: پتید بتا آمیلوئید; Amyloid β peptide; Detergent-insoluble membrane fraction; Docosahexaenoic acid; Learning ability; Alzheimer's disease model rats;
Understanding molecular mechanisms of proteolysis in Alzheimer's disease: Progress toward therapeutic interventions
Keywords: پتید بتا آمیلوئید; Alzheimer's disease; Amyloid β peptide; Senile plaque; Neprilysin; Tau; Neurofibrillary tangle; Calpain; Caspase;
Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease
Keywords: پتید بتا آمیلوئید; AD; Alzheimer's disease; ADR1; alcohol dehydrogenase gene regulator 1; AML1c; core binding factor α, variant c; APP; amyloid β precursor protein; Aβ; amyloid β peptide; CAT; chloramphenicol acetyltransferase; Cdx-1; mammalian homologue to Drosophila c
Protein aggregation and its inhibition in biopharmaceutics
Keywords: پتید بتا آمیلوئید; Protein aggregation; Aggregation mechanism; Protein refolding; Protein formulation; Protein stabilization; Aβ; amyloid β peptide; BSA; bovine serum albumin; CAB; carbonic anhydrase B; CD; circular dichroism; rConIFN; recombinant consensus α-interferon;