NMDA receptor blockade impairs the muscarinic conversion of sub-threshold transient depression into long-lasting LTD in the hippocampus-prefrontal cortex pathway in vivo: Correlation with gamma oscillations

► Pilocarpine converts transient depression into a long-lasting LTD in frontal cortex. ► This form of LTD depends on functional NMDA transmission in the prefrontal cortex. ► AP7 alters muscarinic-induced oscillations in the hippocampus and prefrontal cortex. ► Gamma oscillation positively correlates to synaptic depression in the prefrontal cortex.