Participation of hippocampal agmatine in spatial learning: An in vivo microdialysis study

► Monitored dynamic changes of extracellular agmatine using in vivo microdialysis. ► Water maze training leads to increased levels of agmatine in the hippocampus. ► Swimming only did not affect agmatine levels in the hippocampus. ► Hippocampal agmatine participates in spatial information processing.