Clozapine administration reverses behavioral, neuronal, and nitric oxide disturbances in the neonatal ventral hippocampus rat

► We examine the effect of clozapine in the neonatal ventral hippocampus lesion rats. ► Clozapine reverses the hyperlocomotion observed in novel environment in this rats. ► Clozapine rescued neuronal atrophy in the nucleus accumbens, prefrontal cortex and basolateral-amygdale. ► Clozapine reverses behavioral deficits by modulating neuronal reorganization and nitric oxide levels.