Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex

► The onset of spontaneous seizures was highly variable (3-36 days) with an average latency of 15 days. ► Massive neurodegeneration was already present 24 h after KA-induced seizures. ► Neurons of the proximal subiculum and EC layer III preferentially degenerate. ► Distribution of reactive gliosis roughly matches the pattern of neurodegeneration. ► Time course of reactive gliosis parallels that of epileptogenesis.