کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5815775 | 1115527 | 2012 | 11 صفحه PDF | دانلود رایگان |
Taurine (TAU) is an amino sulfonic acid that plays protective roles against neurochemical impairments induced by ethanol (EtOH). Mounting evidence shows the applicability of zebrafish for evaluating locomotor parameters and anxiety-like behavioral phenotypes after EtOH exposure in a large scale manner. In this study, we assess the effects of TAU pretreatment on the behavior of zebrafish in the open tank after acute 1% EtOH (v/v) exposure (20 and 60Â min of duration) and on brain alcohol contents. The exposure for 20Â min exerted significant anxiolytic effects, which were prevented by 42, 150, and 400Â mg/L TAU. Conversely, the 60-min condition induced depressant/sedative effects, in which the changes on vertical activity were associated to modifications on the exploratory profile. Although all TAU concentrations kept locomotor parameters at basal levels, 150Â mg/L TAU, did not prevent the impairment on vertical activity of EtOH[60]. Despite the higher brain EtOH content detected in the 60-min exposure, 42, 150, and 400Â mg/L TAU attenuated the increase of alcohol content in EtOH[60] group. In conclusion, our data suggest that both protocols of acute EtOH exposure induce significant changes in the spatio-temporal behavior of zebrafish and that TAU may exert a preventive role by antagonizing the effects induced by EtOH possibly due to its neuromodulatory role and also by decreasing brain EtOH levels. The hormetic dose-response of TAU on vertical exploration suggests a complex interaction between TAU and EtOH in the central nervous system.
⺠The effects of taurine and ethanol were evaluated on zebrafish behavior. ⺠Differences in brain alcohol levels could influence the behavior. âºÂ Taurine prevents the alterations on anxiolytic-like behavior promoted by ethanol. ⺠Taurine may prevent ethanol-induced changes on locomotion and exploratory profile. ⺠Taurine antagonizes the effects of different acute ethanol exposure protocols.
Journal: Neuropharmacology - Volume 63, Issue 4, September 2012, Pages 613-623