Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia

► Selective and non-selective NMDA receptor antagonists increase superoxide in adult brain. ► Early-life redox dysregulation induces schizophrenia-like neurochemical disruptions. ► Nox2-gene disruption prevents perinatal ketamine-induced loss of PV expression. ► Although parvalbumin-less, neurons remain alive after early-life manipulations