Dopamine system dysregulation by the hippocampus: Implications for the pathophysiology and treatment of schizophrenia

► The hippocampus has been identified as a site of pathology in schizophrenia. ► Parvalbumin interneuron loss in hippocampus alters the dopamine system. ► Restoring GABA tone in the hippocampus can be achieved by a novel GABA drug.